This study assessed the efficacy of a new Activated Hydrogen Peroxide Wipe and showed the product to be effective.A new activated hydrogen peroxide wipe disinfectant was used to disinfect 10 high-touch surfaces in 72 patient rooms. After cleaning, 99% of surfaces yielded less than 2.5 colony-forming units/cm(2), 75% yielded no growth, and 70% yielded adenosine triphosphate counts of less than 250 relative light units. The new disinfectant was highly effective.